Publications

2016

Liu, Y. ; Frirdich, E. ; Taylor, J. A. ; Chan, A. C. K. ; Blair, K. M. ; Vermeulen, J. ; Ha, R. ; Murphy, M. E. P. ; Salama, N. R. ; Gaynor, E. C. ; Tanner, M. E. A Bacterial Cell Shape-Determining Inhibitor. ACS Chem. Biol. 2016, 11.BibTex

2015

Tanner, M. E. Increasing The Diversity Of Known Pictet-Spenglerases. Chem. Biol. 2015, 22.BibTex

Chan, A. C. K. ; Blair, K. M. ; Liu, Y. ; Frirdich, E. ; Gaynor, E. C. ; Tanner, M. E. ; Salama, N. R. ; Murphy, M. E. P. Helical Shape Of Helicobacter Pylori Requires An Atypical Glutamine As A Zinc Ligand In The Carboxypeptidase Csd4. JOURNAL OF BIOLOGICAL CHEMISTRY2015, 290, 3622-3638.BibTex

Tanner, M. E. Mechanistic Studies On The Indole Prenyltransferases. NATURAL PRODUCT REPORTS 2015, 32, 88-101.BibTex

2014

Awakawa, T. ; Zhang, L. ; Wakimoto, T. ; Hoshino, S. ; Mori, T. ; Ito, T. ; Ishikawa, J. ; Tanner, M. E. ; Abe, I. A Methyltransferase Initiates Terpene Cyclization In Teleocidin B Biosynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2014, 136, 9910-9913.BibTex

2013

Liu, Y. ; Garnham, C. P. ; Roll-Mecak, A. ; Tanner, M. E. Phosphinic Acid-Based Inhibitors Of Tubulin Polyglutamylases. Bioorganic & Medicinal Chemistry Letters 2013, 23, 4408 – 4412.BibTex

Mahmoodi, N. ; Tanner, M. E. Potential Rearrangements In The Reaction Catalyzed By The Indole Prenyltransferase Ftmpt1.ChemBioChem 2013, 14, 2029 – 2037.BibTex

Goble, A. M. ; Toro, R. ; Li, X. ; Ornelas, A. ; Fan, H. ; Eswaramoorthy, S. ; Patskovsky, Y. ; Hillerich, B. ; Seidel, R. ; Sali, A. ; Shoichet, B. K. ; Almo, S. C. ; Swaminathan, S. ; Tanner, M. E. ; Raushel, F. M. Deamination Of 6-Aminodeoxyfutalosine In Menaquinone Biosynthesis By Distantly Related Enzymes. Biochemistry 2013, 52, 6525 – 6536.BibTex

Miyafusa, T. ; Caaveiro, J. M. M. ; Tanaka, Y. ; Tanner, M. E. ; Tsumoto, K. Crystal Structure Of The Capsular Polysaccharide Synthesizing Protein Cape Of Staphylococcus Aureus. Bioscience Reports 2013, 336128294328, 463 – 474.BibTex

Hadi, T. ; Hazra, S. ; Tanner, M. E. ; Blanchard, J. S. Structure Of Murnac 6-Phosphate Hydrolase (Murq) From Haemophilus Influenzae With A Bound Inhibitor. Biochemistry 2013, 52.BibTex

Mahmoodi, N. ; Qian, Q. ; Luk, L. Y. P. ; Tanner, M. E. Rearrangements In The Mechanisms Of Indole Alkaloid Prenyltranferases. Pure App. Chem. 2013, 85.BibTex

2012

Qian, Q. ; Schultz, A. W. ; Moore, B. S. ; Tanner, M. E. Mechanistic Studies On Cymd: A Tryptophan Reverse N -Prenyltransferase.Biochemistry 2012, 51, 7733 – 7739.BibTex

Otto, N. J. ; Green, D. E. ; Masuko, S. ; Mayer, A. ; Tanner, M. E. ; Linhardt, R. J. ; Deangelis, P. L. Structure/function Analysis Of The Pasteurella Multocida Heparosan Synthases: Towards Defining Enzyme Specificity And Engineering Novel Catalysts. The Journal of biological chemistry 2012.BibTex

2011

Mayer, A. ; Gloster, T. M. ; Chou, W. K. ; Vocadlo, D. J. ; Tanner, M. E. 6″-Azido-6″-Deoxy-Udp-N-Acetylglucosamine As A Glycosyltransferase Substrate. Bioorganic & Medicinal Chemistry Letters 2011, 21, 1199 – 1201.BibTex

Luk, L. Y. P. ; Qian, Q. ; Tanner, M. E. A Cope Rearrangement In The Reaction Catalyzed By Dimethylallyltryptophan Synthase?. Journal of the American Chemical Society 2011, 133, 12342 – 12345.BibTex

Li, X. ; Apel, D. ; Gaynor, E. C. ; Tanner, M. E. 5’-Methylthioadenosine Nucleosidase Is Implicated In Playing A Key Role In A Modified Futalosine Pathway For Menaquinone Biosynthesis In Campylobacter Jejuni. Journal of Biological Chemistry 2011, 286, 19392 – 19398.BibTex

Hadi, T. ; Pfeffer, J. M. ; Clarke, A. J. ; Tanner, M. E. Water-Soluble Substrates Of The Peptidoglycan-Modifying Enzyme O-Acetylpeptidoglycan Esterase (Ape1) From Neisseria Gonorrheae. The Journal of Organic Chemistry 2011, 76, 1118 – 1125.BibTex

2010

Li, X. ; Tanner, M. E. An Efficient Synthesis Of Futalosine. Tetrahedron Letters 2010, 51, 6463 – 6465.BibTex

Kowatz, T. ; Morrison, J. P. ; Tanner, M. E. ; Naismith, J. H. The Crystal Structure Of The Y140F Mutant Of Adp-L-Glycero-D-Manno-Heptose 6-Epimerase Bound To Adp-Β-D-Mannose Suggests A One Base Mechanism. Protein Science 2010, 19, 1337 – 1343.BibTex

2009

Liu, F. ; Lee, H. J. ; Strynadka, N. C. J. ; Tanner, M. E. Inhibition Of Neisseria Meningitidis Sialic Acid Synthase By A Tetrahedral Intermediate Analogue. Biochemistry 2009, 48, 9194-9201.BibTex

Luk, L. Y. P. ; Tanner, M. E. Mechanism Of Dimethylallyltryptophan Synthase: Evidence For A Dimethylallyl Cation Intermediate In An Aromatic Prenyltransferase Reaction. Journal of the American Chemical Society 2009, 131, 13932-13933.BibTex

Liu, F. ; Aubry, A. J. ; Schoenhofen, I. C. ; Logan, S. M. ; Tanner, M. E. The Engineering Of Bacteria Bearing Azido-Pseudaminic Acid-Modified Flagella. Chembiochem 2009, 10, 1317-1320.BibTex

2008

Lau, S. T. B. ; Tanner, M. E. Mechanism And Active Site Residues Of Gdp-Fucose Synthase. Journal of the American Chemical Society2008, 130, 17593-17602.BibTex

Morrison, J. P. ; Schoenhofen, I. C. ; Tanner, M. E. Mechanistic Studies On Pseb Of Pseudaminic Acid Biosynthesis: A Udp-N-Acetylglucosamine 5-Inverting 4,6-Dehydratase. Bioorganic Chemistry 2008, 36, 312-320.BibTex

Tanner, M. E. Transient Oxidation As A Mechanistic Strategy In Enzymatic Catalysis. Current Opinion in Chemical Biology 2008, 12, 532-538.BibTex

Hadi, T. ; Dahl, U. ; Mayer, C. ; Tanner, M. E. Mechanistic Studies On N-Acetylmuramic Acid 6-Phosphate Hydrolase (Murq): An Etherase Involved In Peptidoglycan Recycling. Biochemistry 2008, 47, 11547-11558.BibTex

Glaze, P. A. ; Watson, D. C. ; Young, N. M. ; Tanner, M. E. Biosynthesis Of Cmp-N,n’-Diacetyllegionaminic Acid From Udp-N,n’-Diacetylbacillosamine In Legionella Pneumophila. Biochemistry 2008, 47, 3272-3282.BibTex

2007

Luk, L. Y. P. ; Bunn, S. ; Liscombe, D. K. ; Facchini, P. J. ; Tanner, M. E. Mechanistic Studies On Norcoclaurine Synthase Of Benzylisoquinoline Alkaloid Biosynthesis: An Enzymatic Pictet-Spengler Reaction. Biochemistry 2007, 46, 10153-10161.BibTex

Mayer, A. ; Tanner, M. E. Intermediate Release By Adp-L-Glycero-D-Manno-Heptose 6-Epimerase. Biochemistry 2007, 46, 6149-6155.BibTex

Morrison, J. P. ; Tanner, M. E. A Two-Base Mechanism For Escherichia Coli Adp-L-Glycero-D-Manno-Heptose 6-Epimerase. Biochemistry2007, 46, 3916-3924.BibTex

2006

Liu, F. ; Tanner, M. E. Pseg Of Pseudaminic Acid Biosynthesis – A Udp-Sugar Hydrolase As A Masked Glycosyltransferase. Journal of Biological Chemistry 2006, 281, 20902-20909.BibTex

2005

Chou, W. K. ; Dick, S. ; Wakarchuk, W. W. ; Tanner, M. E. Identification And Characterization Of Neub3 From Campylobacter Jejuni As A Pseudaminic Acid Synthase. Journal of Biological Chemistry 2005, 280, 35922-35928.BibTex

Read, J. A. ; Ahmed, R. A. ; Tanner, M. E. Efficient Chemoenzymatic Synthesis Of Adp-D-Glycero-Beta-D-Manno-Heptose And A Mechanistic Study Of Adp-L-Glycero-D-Manno-Heptose 6-Epimerase. Organic Letters 2005, 7, 2457-2460.BibTex

Tanner, M. E. The Enzymes Of Sialic Acid Biosynthesis. Bioorganic Chemistry 2005, 33, 216-228.BibTex

Gunawan, J. ; Simard, D. ; Gilbert, M. ; Lovering, A. L. ; Wakarchuk, W. W. ; Tanner, M. E. ; Strynadka, N. C. J. Structural And Mechanistic Analysis Of Sialic Acid Synthase Neub From Neisseria Meningitidis In Complex With Mn2+ Phosphoenolpyruvate, And N-Acetylmannosaminitol. Journal of Biological Chemistry 2005, 280, 3555-3563.BibTex

Morrison, J. P. ; Read, J. A. ; Coleman, W. G. ; Tanner, M. E. Dismutase Activity Of Adp-L-Glycero-D-Manno-Heptose 6-Epimerase: Evidence For A Direct Oxidation/reduction Mechanism. Biochemistry 2005, 44, 5907-5915.BibTex

2004

Murkin, A. S. ; Chou, W. K. ; Wakarchuk, W. W. ; Tanner, M. E. Identification And Mechanism Of A Bacterial Hydrolyzing Udp-N-Acetylglucosamine 2-Epimerase. Biochemistry 2004, 43, 14290-14298.BibTex

Samuel, J. ; Tanner, M. E. Active Site Mutants Of The “non-Hydrolyzing” Udp-N-Acetylglucosamine 2-Epimerase From Escherichia Coli.Biochimica Et Biophysica Acta-Proteins and Proteomics 2004, 1700, 85-91.BibTex

Read, J. A. ; Ahmed, R. A. ; Morrison, J. P. ; Coleman, W. G. ; Tanner, M. E. The Mechanism Of The Reaction Catalyzed By Adp-Beta-L-Glycero-D-Manno-Heptose 6-Epimerase. Journal of the American Chemical Society 2004, 126, 8878-8879.BibTex

Ge, X. ; Penney, L. C. ; van de Rijn, I. ; Tanner, M. E. Active Site Residues And Mechanism Of Udp-Glucose Dehydrogenase. European Journal of Biochemistry 2004, 271, 14-22.BibTex

Vann, W. F. ; Daines, D. A. ; Murkin, A. S. ; Tanner, M. E. ; Chaffin, D. O. ; Rubens, C. E. ; Vionnet, J. ; Silver, R. P. The Neuc Protein Of Escherichia Coli K1 Is A Udp N-Acetylglucosamine 2-Epimerase. Journal of Bacteriology 2004, 186, 706-712.BibTex

2003

Chou, W. K. ; Hinderlich, S. ; Reutter, W. ; Tanner, M. E. Sialic Acid Biosynthesis: Stereochemistry And Mechanism Of The Reaction Catalyzed By The Mammalian Udp-N-Acetylglucosamine 2-Epimerase. Journal of the American Chemical Society 2003, 125, 2455-2461.BibTex

2002

Murkin, A. S. ; Tanner, M. E. Dehydroalanine-Based Inhibition Of A Peptide Epimerase From Spider Venom. Journal of Organic Chemistry2002, 67, 8389-8394.BibTex

Samuel, J. ; Tanner, M. E. Mechanistic Aspects Of Enzymatic Carbohydrate Epimerization. Natural Product Reports 2002, 19, 261-277.BibTex

Tanner, M. E. ; Chou, W. K. ; Reutter, W. ; Hinderlich, S. Stereochemistry And Mechanism Of The Reaction Catalyzed By The Mammalian Udp-Glcnac 2-Epimerase. Biochemistry 2002, 41, 82.BibTex

Tanner, M. E. Understanding Nature’S Strategies For Enzyme-Catalyzed Racemization And Epimerization. Accounts of Chemical Research2002, 35, 237-246.BibTex

2001

Glavas, S. ; Tanner, M. E. Active Site Residues Of Glutamate Racemase. Biochemistry 2001, 40, 6199-6204.BibTex

Tanner, M. E. Sugar Nucleotide-Modifying Enzymes. Current Organic Chemistry 2001, 5, 169-192.BibTex

Samuel, J. ; Luo, Y. ; Morgan, P. M. ; Strynadka, N. C. J. ; Tanner, M. E. Catalysis And Binding In L-Ribulose-5-Phosphate 4-Epimerase: A Comparison With L-Fuculose-1-Phosphate Aldolase. Biochemistry 2001, 40, 14772-14780.BibTex

Luo, Y. ; Samuel, J. ; Mosimann, S. C. ; Lee, J. E. ; Tanner, M. E. ; Strynadka, N. C. J. The Structure Of L-Ribulose-5-Phosphate 4-Epimerase: An Aldolase-Like Platform For Epimerization. Biochemistry 2001, 40, 14763-14771.BibTex

2000

Campbell, R. E. ; Mosimann, S. C. ; van de Rijn, I. ; Tanner, M. E. ; Strynadka, N. C. J. The First Structure Of Udp-Glucose Dehydrogenase Reveals The Catalytic Residues Necessary For The Two-Fold Oxidation. Biochemistry 2000, 39, 7012-7023.BibTex

Tanner, M. E. ; Campbell, R. E. ; Ge, X. ; Mossiman, S. ; Strynadka, N. C. J. Covalent Catalysis With Udp-Glucose Dehydrogenase.Biochemistry 2000, 39, 2.BibTex

Campbell, R. E. ; Mosimann, S. C. ; Tanner, M. E. ; Strynadka, N. C. J. The Structure Of Udp-N-Acetylglucosamine 2-Epimerase Reveals Homology To Phosphoglycosyl Transferases. Biochemistry 2000, 39, 14993-15001.BibTex

1999

Galpin, J. D. ; Ellis, B. E. ; Tanner, M. E. The Inactivation Of Histidine Ammonia-Lyase By L-Cysteine And Oxygen: Modification Of The Electrophilic Center. Journal of the American Chemical Society 1999, 121, 10840-10841.BibTex

Glavas, S. ; Tanner, M. E. Catalytic Acid/base Residues Of Glutamate Racemase. Biochemistry 1999, 38, 4106-4113.BibTex

Campbell, R. E. ; Tanner, M. E. Udp-Glucose Analogues As Inhibitors And Mechanistic Probes Of Udp-Glucose Dehydrogenase. Journal of Organic Chemistry 1999, 64, 9487-9492.BibTex

1998

Sala, R. F. ; MacKinnon, S. L. ; Palcic, M. M. ; Tanner, M. E. Udp-N-Trifluoroacetylglucosamine As An Alternative Substrate In N-Acetylglucosaminyltransferase Reactions. Carbohydrate Research 1998, 306, 127-136.BibTex

Zeng, B. Q. ; Kwong, K. ; Pompliano, D. L. ; Reddy, S. ; Tanner, M. E. A Phosphinate Inhibitor Of The Meso-Diaminopimelic Acid-Adding Enzyme (Mure) Of Peptidoglycan Biosynthesis. Journal of Organic Chemistry 1998, 63, 10081-10085.BibTex

Johnson, A. E. ; Tanner, M. E. Epimerization Via Carbon-Carbon Bond Cleavage. L-Ribulose-5-Phosphate 4-Epimerase As A Masked Class Ii Aldolase. Biochemistry 1998, 37, 5746-5754.BibTex

Ge, X. ; Campbell, R. E. ; van de Rijn, I. ; Tanner, M. E. Covalent Adduct Formation With A Mutated Enzyme: Evidence For A Thioester Intermediate In The Reaction Catalyzed By Udp-Glucose Dehydrogenase. Journal of the American Chemical Society 1998, 120, 6613-6614.BibTex

1997

Glavas, S. ; Tanner, M. E. The Inhibition Of Glutamate Racemase By D-N-Hydroxyglutamate. Bioorganic & Medicinal Chemistry Letters1997, 7, 2265-2270.BibTex

Morgan, P. M. ; Sala, R. F. ; Tanner, M. E. Eliminations In The Reactions Catalyzed By Udp-N-Acetylglucosamine 2-Epimerase. Journal of the American Chemical Society 1997, 119, 10269-10277.BibTex

Campbell, R. E. ; Sala, R. F. ; vandeRijn, I. V. ; Tanner, M. E. Properties And Kinetic Analysis Of Udp-Glucose Dehydrogenase From Group A Streptococci – Irreversible Inhibition By Udp-Chloroacetol. Journal of Biological Chemistry 1997, 272, 3416-3422.BibTex

Campbell, R. E. ; Tanner, M. E. Uridine Diphospho-Alpha-D-Gluco-Hexodialdose: Synthesis And Kinetic Competence In The Reaction Catalyzed By Udp-Glucose Dehydrogenase. Angewandte Chemie-International Edition in English 1997, 36, 1520-1522.BibTex

1996

Sala, R. F. ; Morgan, P. M. ; Tanner, M. E. Enzymatic Formation And Release Of A Stable Glycal Intermediate: The Mechanism Of The Reaction Catalyzed By Udp-N-Acetylglucosamine 2-Epimerase. Journal of the American Chemical Society 1996, 118, 3033-3034.BibTex

Tanner, M. E. ; Vaganay, S. ; vanHeijenoort, J. ; Blanot, D. Phosphinate Inhibitors Of The D-Glutamic Acid-Adding Enzyme Of Peptidoglycan Biosynthesis. Journal of Organic Chemistry 1996, 61, 1756-1760.BibTex

1994

Tanner, M. E. ; Miao, S. C. The Synthesis And Stability Of Aziridino-Glutamate, An Irreversible Inhibitor Of Glutamate Racemase.Tetrahedron Letters 1994, 35, 4073-4076.BibTex